Gene
ahsg2
- ID
- ZDB-GENE-030131-1133
- Name
- alpha-2-HS-glycoprotein 2
- Symbol
- ahsg2 Nomenclature History
- Previous Names
-
- fb60d10
- si:ch73-252g14.4
- si:cu104710.4
- wu:fb60d10
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in acute-phase response; negative regulation of bone mineralization; and regulation of inflammatory response. Predicted to be located in extracellular space and membrane. Predicted to be active in extracellular matrix and extracellular region. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human AHSG (alpha 2-HS glycoprotein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001363 | Proteinase inhibitor I25C, fetuin, conserved site |
| Domain | IPR000010 | Cystatin domain |
| Domain | IPR025760 | Fetuin-A-type cystatin domain |
| Family | IPR050735 | Kininogen/Fetuin/Histidine-rich Glycoprotein |
| Homologous_superfamily | IPR046350 | Cystatin superfamily |
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Domain Details Per Protein
| Protein | Length | Cystatin domain | Cystatin superfamily | Fetuin-A-type cystatin domain | Kininogen/Fetuin/Histidine-rich Glycoprotein | Proteinase inhibitor I25C, fetuin, conserved site |
|---|---|---|---|---|---|---|
|
UniProtKB:A5WWI5
|
386 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-252G14 | ZFIN Curated Data | |
| Encodes | EST | fb60d10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100029 (1) | 1488 nt | ||
| Genomic | GenBank:CU104710 (2) | 93492 nt | ||
| Polypeptide | UniProtKB:A5WWI5 (1) | 386 aa |
No data available
- Bao, J., Su, B., Chen, Z., Sun, Z., Peng, J., Zhao, S. (2024) A UTP3-dependent nucleolar translocation pathway facilitates pre-rRNA 5'ETS processing. Nucleic acids research. 52(16):9671-9694
- Freeburg, S.H., Shwartz, A., Kemény, L.V., Smith, C.J., Weeks, O., Miller, B.M., PenkoffLidbeck, N., Fisher, D.E., Evason, K.J., Goessling, W. (2024) Hepatocyte vitamin D receptor functions as a nutrient sensor that regulates energy storage and tissue growth in zebrafish. Cell Reports. 43:114393114393
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Ortiz-Villanueva, E., Navarro-Martín, L., Jaumot, J., Benavente, F., Sanz-Nebot, V., Piña, B., Tauler, R. (2017) Metabolic disruption of zebrafish (Danio rerio) embryos by bisphenol A. An integrated metabolomic and transcriptomic approach. Environmental pollution (Barking, Essex : 1987). 231:22-36
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kessels, M.Y., Huitema, L.F., Boeren, S., Kranenbarg, S., Schulte-Merker, S., van Leeuwen, J.L., de Vries, S.C. (2014) Proteomics analysis of the zebrafish skeletal extracellular matrix. PLoS One. 9:e90568
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